Severe inflammation in new-borns induces long-term cognitive impairment by activation of IL-1β/KCC2 signaling during early development.

ABSTRACT:

Background

Neonatal sepsis can induce long-term cognitive impairment in adolescence or adulthood, but the underlying molecular mechanism is not fully understood. The expression of K⁺-Cl^- co-transporter 2 (KCC2) plays a pivotal role in the GABAergic shift from depolarizing to hyperpolarizing during early postnatal development. In this study, we aimed to determine whether neonatal severe inflammation-induced cognitive impairment was associated with the expression of KCC2 during early development.

Methods

Neonatal severe inflammation was established by intraperitoneal injection of high dose lipopolysaccharide (LPS, 1 mg kg^-1) in postnatal day 3 (P3) rats. The Morris water maze task and fear conditioning test were used to investigate long-term co

SUBMITTER: Zhang D 

PROVIDER: S-EPMC9327322 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature