Dynamic transcriptome analysis of NFAT family in guided bone regeneration with occlusive periosteum in swine model.

ABSTRACT:

Objective

To investigate the dynamic expression of NFAT family of periosteum in guided bone regeneration process.

Material and methods

The swine ribs on one side were used as the trauma group and the contralateral side as the control group. After rib segment was removed, periosteum was sutured to form a closed cavity mimicking guided bone regeneration. The periosteum and regenerated bone tissue were collected at nine time points for gene sequencing and hematoxylin-eosin staining. The expression data of each member were extracted for analysis. Expression correlations among various members were analyzed.

Results

Staining showed the guided bone regeneration was almost completed 1 month after the operation with later stage for bone remodeling. The expression levels of eac

SUBMITTER: Yu BF 

PROVIDER: S-EPMC9327338 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature