Protocol for a multi-center randomized controlled trial to evaluate the benefits of exercise incentives and corticosteroid injections in osteoarthritis of the knee (MOVE-OK).

ABSTRACT:

Background

Knee osteoarthritis (KOA) is a high-priority problem among the aging population. While exercise has been shown to be beneficial in management of the disease, scalable and low-cost interventions to improve exercise in this population are lacking. Recent controversy over the value of corticosteroid injections for palliation has also arisen. Therefore, we designed a randomized, double-blind, placebo-controlled clinical trial with a 2-period crossover design to study (1) behavioral incentives to promote exercise and (2) corticosteroid injections to reduce pain and improve function in patients with KOA when compared to lidocaine only.

Methods

The study design is a pragmatic factorial and crossover randomized clinical trial. Patients with KOA who are deemed eligible by

SUBMITTER: Leach W 

PROVIDER: S-EPMC9327347 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature