Activation of CD81⁺ skin ILC2s by cold-sensing TRPM8⁺ neuron-derived signals maintains cutaneous thermal homeostasis.

ABSTRACT: As the outermost barrier tissue of the body, the skin harbors a large number of innate lymphoid cells (ILCs) that help maintain local homeostasis in the face of changing environments. How skin-resident ILCs are regulated and function in local homeostatic maintenance is poorly understood. We here report the discovery of a cold-sensing neuron-initiated pathway that activates skin group 2 ILCs (ILC2s) to help maintain thermal homeostasis. In stearoyl-CoA desaturase 1 (SCD1) knockout mice whose skin is defective in heat maintenance, chronic cold stress induced excessive activation of CCR10^-CD81⁺ST2⁺ skin ILC2s and associated inflammation. Mechanistically, stimulation of the cold-sensing receptor TRPM8 expressed in sensory neurons of the skin led to increased pr

SUBMITTER: Xu M 

PROVIDER: S-EPMC9327500 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature