Effect of Intravitreal Aflibercept vs Laser Photocoagulation on Treatment Success of Retinopathy of Prematurity: The FIREFLEYE Randomized Clinical Trial.

ABSTRACT:

Importance

Laser photocoagulation, which is the standard treatment for retinopathy of prematurity (ROP), can have adverse events. Studies of anti-vascular endothelial growth factor injections have suggested efficacy in the treatment of ROP, but few studies have directly compared them with laser treatments.

Objective

To compare intravitreal aflibercept vs laser photocoagulation in infants with ROP requiring treatment.

Design, setting, and participants

This noninferiority, phase 3, 24-week, randomized clinical trial was conducted in 27 countries (64 hospital sites) throughout Asia, Europe, and South America. Overall, 118 infants (gestational age ≤32 weeks at birth or birth weight ≤1500 g) with ROP severity (zone I stage 1+ [stage 1 plus increased disease activity], zone

SUBMITTER: Stahl A 

PROVIDER: S-EPMC9327573 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature