Population-based randomized trial of screening for clinically significant prostate cancer ProScreen: a pilot study.

ABSTRACT:

Objectives

To evaluate the feasibility of a population-based screening trial using prostate-specific antigen (PSA), a kallikrein panel and multiparametric magnetic resonance imaging (MRI) aimed at minimizing overdiagnosis, while retaining mortality benefit.

Patients and methods

Feasibility of the screening algorithm was evaluated in terms of participation, screening test results and cancer detection. A random sample of 400 men aged 65 years was identified from the population registry and invited for screening with three stepwise tests (PSA, kallikrein panel and MRI). Men with PSA levels ≥3 ng/mL were further tested with the kallikrein panel, and those with positive findings (risk >7.5%) were referred for prostate MRI. Men with positive MRI (Prostate Imaging Reporting and Dat

SUBMITTER: Rannikko A 

PROVIDER: S-EPMC9327584 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature