Serum proteome modulations upon treatment provides biological insight on response to treatment in relapsed mantle cell lymphoma.

ABSTRACT:

Background

The possibility to monitor patient's serum proteome during treatment can provide deepened understanding of the biology associated with response to specific drugs. Non-invasive serum sampling provides an opportunity for sustainable repetitive sampling of patients, which allows for more frequent evaluation of the biological response and enhanced flexibility in treatment selection in contrast to tissue biopsies.

Aim

To pin-point biologically relevant changes in pre- and on-treatment serum proteome samples in relapsed mantle cell lymphoma (MCL) patients, leading to insight into mechanisms behind response to treatment in sub-groups of patients.

Methods

Pre- and on-treatment serum samples from relapsed MCL patients treated with a triple combination therapy of rit

SUBMITTER: Lokhande L 

PROVIDER: S-EPMC9327662 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature