Identification of PSMD14 as a potential novel prognosis biomarker and therapeutic target for osteosarcoma.

ABSTRACT:

Background

Osteosarcoma is the most common primary bone tumor. The survival rate of osteosarcoma patients has not significantly increased in the past decades. Uncovering the mechanisms of malignancy, progression, and metastasis will shed light on the development of new therapeutic targets and treatment for osteosarcoma.

Aim

The aim of this study is to identify potential osteosarcoma biomarker and/or therapeutic targets by using integrated bioinformatics analysis.

Methods and results

We utilized existing gene expression datasets to identify differential expressed genes (DEGs) that could serve as osteosarcoma biomarkers or even as therapeutic targets. We found 48 DEGs were overlapped in three datasets. Among these 48 DEGs, PSMD14 was on the top of the up-regulated gene

SUBMITTER: Gong Y 

PROVIDER: S-EPMC9327663 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature