Endocytosed HIV-1 Envelope Glycoprotein Traffics to Rab14⁺ Late Endosomes and Lysosomes to Regulate Surface Levels in T-Cell Lines.

ABSTRACT: Production of infectious HIV-1 particles requires incorporation of the viral envelope glycoprotein (Env) at the plasma membrane (PM) of infected CD4⁺ T cells. Env trafficking to the PM exposes viral epitopes that can be exploited by the host immune system; however, HIV-1 can evade this response by endocytosis of excess Env from the PM. The fate of Env after internalization remains unclear, with evidence suggesting several different vesicular trafficking steps may be involved, including recycling pathways. To date, there have been very few studies documenting the trafficking pathways of native Env in infected T cells. Furthermore, it remains unclear whether there are T-cell-specific endosomal pathways regulating the fate of endocytic Env. Here, we use a pulse-labeling approach wi

SUBMITTER: Hoffman HK 

PROVIDER: S-EPMC9327703 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature