Reduced kidney function is associated with poorer domain-specific cognitive performance in community-dwelling older adults.

ABSTRACT:

Objectives

Whilst chronic kidney disease has been associated with cognitive impairment, the association between reduced estimated Glomerular Filtration Rate (eGFR) and domain-specific cognitive performance is less clear and may represent an important target for the promotion of optimal brain health in older adults.

Methods

Participants aged >60 years from the Trinity-Ulster-Department of Agriculture study underwent detailed cognitive assessment using the Mini-Mental State Examination (Mini-Mental State Examination (MMSE)), Frontal Assessment Battery (FAB) and Repeatable Battery for Assessment of Neuropsychological Status (RBANS). Poisson and linear regression models assessed the relationship between eGFR strata and cognitive performance.

Results

In 4887 older adults (

SUBMITTER: Dyer AH 

PROVIDER: S-EPMC9327725 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature