Placental structure, function, and mitochondrial phenotype relate to fetal size in each fetal sex in mice†.

ABSTRACT: Fetal growth depends on placental function, which requires energy from mitochondria. Here we investigated whether mitochondrial function in the placenta relates to the growth of the lightest and heaviest fetuses of each sex within the litter of mice. Placentas from the lightest and heaviest fetuses were taken to evaluate placenta morphology (stereology), mitochondrial energetics (high-resolution respirometry), mitochondrial regulators, nutrient transporters, hormone handling, and signaling pathways (qPCR and Western blotting). We found that mitochondrial complex I and II oxygen consumption rate was greater for placentas supporting the lightest female fetuses, although placental complex I abundance of the lightest females and complexes III and V of the lightest males were decreased compared

SUBMITTER: Salazar-Petres E 

PROVIDER: S-EPMC9327737 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature