Gut dysbiosis impairs hippocampal plasticity and behaviors by remodeling serum metabolome.

ABSTRACT: Accumulating evidence suggests that gut microbiota as a critical mediator of gut-brain axis plays an important role in human health. Altered gut microbial profiles have been implicated in increasing the vulnerability of psychiatric disorders, such as autism, depression, and schizophrenia. However, the cellular and molecular mechanisms underlying the association remain unknown. Here, we modified the gut microbiome with antibiotics in newborn mice, and found that gut microbial alteration induced behavioral impairment by decreasing adult neurogenesis and long-term potentiation of synaptic transmission, and altering the gene expression profile in hippocampus. Reconstitution with normal gut flora produced therapeutic effects against both adult neurogenesis and behavioral deficits in the dysbios

SUBMITTER: Liu G 

PROVIDER: S-EPMC9327780 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature