Complement Is Activated During Normothermic Machine Perfusion of Porcine and Human Discarded Kidneys.

ABSTRACT:

Background

The gap between demand and supply of kidneys for transplantation necessitates the use of kidneys from extended criteria donors. Transplantation of these donor kidneys is associated with inferior results, reflected by an increased risk of delayed graft function. Inferior results might be explained by the higher immunogenicity of extended criteria donor kidneys. Normothermic machine perfusion (NMP) could be used as a platform to assess the quality and function of donor kidneys. In addition, it could be useful to evaluate and possibly alter the immunological response of donor kidneys. In this study, we first evaluated whether complement was activated during NMP of porcine and human discarded kidneys. Second, we examined the relationship between complement activation and pro

SUBMITTER: Jager NM 

PROVIDER: S-EPMC9327788 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature