Novel Insights into Alcoholic Liver Disease: Iron Overload, Iron Sensing and Hemolysis.

ABSTRACT: The liver is the major target organ of continued alcohol consumption at risk and resulting alcoholic liver disease (ALD) is the most common liver disease worldwide. The underlying molecular mechanisms are still poorly understood despite decades of scientific effort limiting our abilities to identify those individuals who are at risk to develop the disease, to develop appropriate screening strategies and, in addition, to develop targeted therapeutic approaches. ALD is predestined for the newly evolving translational medicine, as conventional clinical and health care structures seem to be constrained to fully appreciate this disease. This concept paper aims at summarizing the 15 years translational experience at the Center of Alcohol Research in Heidelberg, namely based on the long-term pros

SUBMITTER: Mueller S 

PROVIDER: S-EPMC9328032 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature