Parametric and non-parametric estimation of reference intervals for routine laboratory tests: an analysis of health check-up data for 260 889 young men in the South Korean military.

ABSTRACT:

Objectives

Determination of reference intervals (RIs) using big data faces several obstacles due to heterogeneity in analysers, period and ethnicity. The present study aimed to establish the RIs for routine common blood count (CBC) and biochemistry laboratory tests in homogeneous, healthy, male Korean soldiers in their 20s using a large health check-up data set, comparing parametric and non-parametric estimation.

Design

A multicentre, cross-sectional study.

Setting

Seven armed forces hospitals in South Korea.

Participants

A total of 609 649 men underwent health examination when promoted to corporal between January 2015 and September 2021. 260 889 eligible individuals aged 20-25 were included in the analysis.

Main outcomes and measures

The RIs were establ

SUBMITTER: Kim T 

PROVIDER: S-EPMC9328105 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature