An extract of Leontopodium alpinum inhibits catagen development ex vivo and increases hair density in vivo.

ABSTRACT:

Objectives

Hair loss and reduction in hair volume are hallmarks of hair disorders, such as telogen effluvium, or male or female pattern hair loss, and hair ageing, which can cause severe distress in both men and women. Common anti-hair loss drugs carry some side effects; therefore, novel, safer approaches targeting milder phenotypes are highly advocated. In this context, we investigated an extract of the alpine plant Edelweiss, Leontopodium alpinum var. Helvetia, for its ability to modulate hair follicle (HF) growth ex vivo and inhibit hair loss while increasing hair regeneration in vivo.

Methods

Human amputated HFs were microdissected from three donors, two women and one man, and cultured ex vivo for 6 days. After treatment with 0.001% Edelweiss extract (EWDE), we investiga

SUBMITTER: Campiche R 

PROVIDER: S-EPMC9328135 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature