Homology-based classification of accessory proteins in coronavirus genomes uncovers extremely dynamic evolution of gene content.

ABSTRACT: Coronaviruses (CoVs) have complex genomes that encode a fixed array of structural and nonstructural components, as well as a variety of accessory proteins that differ even among closely related viruses. Accessory proteins often play a role in the suppression of immune responses and may represent virulence factors. Despite their relevance for CoV phenotypic variability, information on accessory proteins is fragmentary. We applied a systematic approach based on homology detection to create a comprehensive catalogue of accessory proteins encoded by CoVs. Our analyses grouped accessory proteins into 379 orthogroups and 12 super-groups. No orthogroup was shared by the four CoV genera and very few were present in all or most viruses in the same genus, reflecting the dynamic evolution of CoV geno

SUBMITTER: Forni D 

PROVIDER: S-EPMC9328142 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature