Why we should sample sparsely and aim for a higher target: Lessons from model-based therapeutic drug monitoring of vancomycin in intensive care patients.

ABSTRACT:

Aims

To explore the optimal data sampling scheme and the pharmacokinetic (PK) target exposure on which dose computation is based in the model-based therapeutic drug monitoring (TDM) practice of vancomycin in intensive care (ICU) patients.

Methods

We simulated concentration data for 1 day following four sampling schemes, C_min , C_max + C_min , C_max + C_mid-interval + C_min , and rich sampling where a sample was drawn every hour within a dose interval. The datasets were used for Bayesian estimation to obtain PK parameters, which were used to compute the doses for the next day based on five PK target exposures: AUC₂₄ = 400, 500, and 600 mg·h/L and C_min = 15 and 20 mg/L. We then simulated data fo

SUBMITTER: Guo T 

PROVIDER: S-EPMC9328201 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature