Cardiovascular disease related circulating biomarkers and cancer incidence and mortality: is there an association?

ABSTRACT:

Aims

Recent studies suggest an association between cardiovascular disease (CVD) and cancer incidence/mortality, but the pathophysiological mechanisms underlying these associations are unclear. We aimed to examine biomarkers previously associated with CVD and study their association with incident cancer and cancer-related death in a prospective cohort study.

Methods and results

We used a proteomic platform to measure 71 cardiovascular biomarkers among 5032 participants in the Framingham Heart Study who were free of cancer at baseline. We used multivariable-adjusted Cox models to examine the association of circulating protein biomarkers with risk of cancer incidence and mortality. To account for multiple testing, we set a 2-sided false discovery rate <0.05. Growth differentiat

SUBMITTER: Jovani M 

PROVIDER: S-EPMC9328284 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature