Optical ventricular cardioversion by local optogenetic targeting and LED implantation in a cardiomyopathic rat model.

ABSTRACT:

Aims

Ventricular tachyarrhythmias (VTs) are common in the pathologically remodelled heart. These arrhythmias can be lethal, necessitating acute treatment like electrical cardioversion to restore normal rhythm. Recently, it has been proposed that cardioversion may also be realized via optically controlled generation of bioelectricity by the arrhythmic heart itself through optogenetics and therefore without the need of traumatizing high-voltage shocks. However, crucial mechanistic and translational aspects of this strategy have remained largely unaddressed. Therefore, we investigated optogenetic termination of VTs (i) in the pathologically remodelled heart using an (ii) implantable multi-LED device for (iii) in vivo closed-chest, local illumination.

Methods and results

In orde

SUBMITTER: Nyns ECA 

PROVIDER: S-EPMC9328286 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature