NH-sulfoximine: A novel pharmacological inhibitor of the mitochondrial F₁ F_o -ATPase, which suppresses viability of cancerous cells.

ABSTRACT:

Background and purpose

The mitochondrial F₁ F_o -ATPsynthase is pivotal for cellular homeostasis. When respiration is perturbed, its mode of action everts becoming an F₁ F_o -ATPase and therefore consuming rather producing ATP. Such a reversion is an obvious target for pharmacological intervention to counteract pathologies. Despite this, tools to selectively inhibit the phases of ATP hydrolysis without affecting the production of ATP remain scarce. Here, we report on a newly synthesised chemical, the NH-sulfoximine (NHS), which achieves such a selectivity.

Experimental approach

The chemical structure of the F₁ F_o -ATPase inhibitor BTB-06584 was used as a template to synthesise NHS. We assessed its pharmacology i

SUBMITTER: Strobbe D 

PROVIDER: S-EPMC9328437 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature