The human G protein-coupled ATP receptor P2Y₁₁ is a target for anti-inflammatory strategies.

ABSTRACT:

Background and purpose

The ATP receptor P2Y₁₁ , which couples to G_q and G_s proteins, senses cell stress and promotes cytoprotective responses. P2Y₁₁ receptors are upregulated during differentiation of M2 macrophages. However, it is unclear whether and how P2Y₁₁ receptors contribute to the anti-inflammatory properties of M2 macrophages.

Experimental approach

Transcriptome and secretome profiling of ectopic P2Y₁₁ receptors was used to analyse their signalling and function. Findings were validated in human monocyte-derived M2 macrophages. The suramin analogue NF340 and P2Y₁₁ receptor-knockout cells confirmed that agonist-mediated responses were specific to P2Y₁₁ receptor stimulation.

Key

SUBMITTER: Gruenbacher G 

PROVIDER: S-EPMC9328440 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature