Antiviral drug treatment for nonsevere COVID-19: a systematic review and network meta-analysis.

ABSTRACT:

Background

Randomized trial evidence suggests that some antiviral drugs are effective in patients with COVID-19. However, the comparative effectiveness of antiviral drugs in nonsevere COVID-19 is unclear.

Methods

We searched the Epistemonikos COVID-19 L·OVE (Living Overview of Evidence) database for randomized trials comparing antiviral treatments, standard care or placebo in adult patients with nonsevere COVID-19 up to Apr. 25, 2022. Reviewers extracted data and assessed risk of bias. We performed a frequentist network meta-analysis and assessed the certainty of evidence using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach.

Results

We identified 41 trials, which included 18 568 patients. Compared with standard care or placebo,

SUBMITTER: Pitre T 

PROVIDER: S-EPMC9328465 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature