Short communication: Comments on hair disorders associated with dupilumab based on VigiBase.

ABSTRACT:

Background

Dupilumab is a human antibody that blocks the signaling of both interleukin-4 and interleukin-13 receptors. It has been approved for the treatment of moderate-to-severe atopic dermatitis. However, several case reports have reported conflicting effects of dupilumab on alopecia.

Objectives

This study aimed to examine dupilumab-related hair disorders using the large real-world database, VigiBase.

Methods

All individual case safety reports associated with dupilumab in the Uppsala Monitoring Center VigiBase until December 29, 2019, were analyzed. Hair disorder-related terms were defined in High Level Terms with "alopecias," "pilar disorders NEC (not elsewhere classified)," and "hypertrichoses," using the Medical Dictionary for Regulatory Activities Hierarchy. Ha

SUBMITTER: Park S 

PROVIDER: S-EPMC9328572 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature