De-escalating Surgery Among Patients with HER2 + and Triple Negative Breast Cancer.

ABSTRACT:

Purpose of review

De-escalation of surgery has been central in the evolution of multidisciplinary management of breast cancer. Advances in oncology and increasing use of neoadjuvant chemotherapy (NACT) have opened opportunities for further surgical de-escalation especially for HER2 + and triple negative (TN) disease. The aim of this review is to discuss the recent data on de-escalation of surgery as well as the future directions.

Recent findings

Patients with TN and HER2 + breast cancer with excellent response to NACT would be the ideal candidates for surgical de-escalation. Post-NACT image-guided biopsy, potentially combined with machine learning algorithms, may accurately identify patients achieving pathologic complete response that would be eligible for clinical trials as

SUBMITTER: Tasoulis MK 

PROVIDER: S-EPMC9328618 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature