Salvage resection plus cesium-131 brachytherapy durably controls post-SRS recurrent brain metastases.

ABSTRACT:

Background

Salvage of recurrent previously irradiated brain metastases (rBrM) is a significant challenge. Resection without adjuvant re-irradiation is associated with a high local failure rate, while reirradiation only partially reduces failure but is associated with greater radiation necrosis risk. Salvage resection plus Cs131 brachytherapy may offer dosimetric and biologic advantages including improved local control versus observation, with reduced normal brain dose versus re-irradiation, however data are limited.

Methods

A prospective registry of consecutive patients with post-stereotactic radiosurgery (SRS) rBrM undergoing resection plus implantation of collagen-matrix embedded Cs131 seeds (GammaTile, GT Medical Technologies) prescribed to 60 Gy at 5 mm from the cavity w

SUBMITTER: Imber BS 

PROVIDER: S-EPMC9328626 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature