Risperidone plasma concentrations are associated with side effects and effectiveness in children and adolescents with autism spectrum disorder.

ABSTRACT:

Aim

Risperidone is the most commonly prescribed antipsychotic drug to children and adolescents worldwide, but it is associated with serious side effects, including weight gain. This study assessed the relationship of risperidone and 9-hydroxyrisperidone trough concentrations, maximum concentrations and 24-hour area under the curves (AUCs) with body mass index (BMI) z-scores in children and adolescents with autism spectrum disorder (ASD) and behavioural problems. Secondary outcomes were metabolic, endocrine, extrapyramidal and cardiac side effects and effectiveness.

Methods

Forty-two children and adolescents (32 males) aged 6-18 years were included in a 24-week prospective observational trial. Drug plasma concentrations, side effects and effectiveness were measured at several

SUBMITTER: Kloosterboer SM 

PROVIDER: S-EPMC9328651 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature