M351-0056 is a novel low MW compound modulating the actions of the immune-checkpoint protein VISTA.

ABSTRACT:

Background and purpose

The protein V-domain immunoglobulin suppressor of T-cell activation (VISTA) is a novel immune-checkpoint molecule that belongs to the B7 family and regulates a broad spectrum of immune responses. So far, low MW compounds targeting VISTA for the treatment of autoimmune diseases or inflammation, have not been identified.

Experimental approach

We developed a homology modelling for VISTA 3D structure and subsequent virtual screening for low MW ligands binding to VISTA. Visualization of the binding postures of docked ligands with protein VISTA indicated that compound M351-0056 targeted VISTA. The biological activities of compound M351-0056 targeting VISTA were investigated in vitro using monocytes and T cells and in vivo, using mice with imiquimod-induced d

SUBMITTER: Hu X 

PROVIDER: S-EPMC9328666 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature