Augmentation strategies for treatment resistant major depression: A systematic review and network meta-analysis.

ABSTRACT:

Objective

To compare the efficacy and discontinuation of augmentation agents in adult patients with treatment-resistant depression (TRD). We conducted a systematic review and network meta-analyses (NMA) to combine direct and indirect comparisons of augmentation agents.

Methods

We included randomized controlled trials comparing one active drug with another or with placebo following a treatment course up to 24 weeks. Nineteen agents were included: stimulants, atypical antipsychotics, thyroid hormones, antidepressants, and mood stabilizers. Data for response/remission and all-cause discontinuation rates were analyzed. We estimated effect-size by relative risk using pairwise and NMA with random-effects model.

Results

A total of 65 studies (N = 12,415) with 19 augmentation

SUBMITTER: Nunez NA 

PROVIDER: S-EPMC9328668 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature