Evaluation of the multimorbidity network and its relationship with clinical phenotypes in chronic obstructive pulmonary disease: The GALAXIA study.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous condition, in which taking into consideration clinical phenotypes and multimorbidity is relevant to disease management. Network analysis, a procedure designed to study complex systems, allows to represent connections between the distinct features found in COPD.

Methods

Network analysis was applied to a cohort of patients with COPD in order to explore the degree of connectivity between different diseases, taking into account the presence of two phenotypic traits commonly used to categorize patients in clinical practice: chronic bronchitis (CB⁺ /CB^- ) and the history of previous severe exacerbations (Ex⁺ /Ex^- ). The strength of association between

SUBMITTER: Figueira-Goncalves JM 

PROVIDER: S-EPMC9329016 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature