Tissue damage detected by quantitative gradient echo MRI correlates with clinical progression in non-relapsing progressive MS.

ABSTRACT:

Background

Imaging biomarkers of progressive multiple sclerosis (MS) are needed. Quantitative gradient recalled echo (qGRE) magnetic resonance imaging (MRI) evaluates microstructural tissue damage in MS.

Objective

To evaluate qGRE-derived R2t* as an imaging biomarker of MS progression compared with atrophy and lesion burden.

Methods

Twenty-three non-relapsing progressive MS (PMS), 22 relapsing-remitting MS (RRMS), and 18 healthy control participants underwent standard MS physical and cognitive neurological assessments and imaging with qGRE, FLAIR, and MPRAGE at 3T. PMS subjects were tested clinically and imaged every 9 months over 45 months. Imaging measures included lesion burden, atrophy, and R2t* in cortical gray matter (GM), deep GM, and normal-appearing white mat

SUBMITTER: Xiang B 

PROVIDER: S-EPMC9329152 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature