Identification and Validation of the Prognostic Impact of Metastatic Prostate Cancer Phenotypes.

ABSTRACT:

Introduction

Castration-sensitive metastatic prostate cancer is heterogeneous. Our objective is to identify metastatic prostate cancer phenotypes and their prognostic impact on survival.

Materials and methods

The National Cancer Database was queried. The Surveillance, Epidemiology, and End Results database was used for validation. Patterns were split into: nonregional lymph node, bone only, and visceral (any brain/liver/lung). Hazard ratios (HR) with 95% confidence intervals (CI) were calculated for the univariate and multivariate Cox proportional hazards regression models, odds ratios were calculated, Kaplan-Meier curves were generated, and a nomogram of the multivariate regression model was created.

Results

The training set included 13,818 men; bone only was most co

SUBMITTER: Labe SA 

PROVIDER: S-EPMC9329179 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature