Photon versus proton whole ventricular radiotherapy for non-germinomatous germ cell tumors: A report from the Children's Oncology Group.

ABSTRACT:

Purpose

To determine if proton therapy reduces doses to cranial organs at risk (OARs) as compared to photon therapy in children with non-germinomatous germ cell tumors (NGGCT) receiving whole ventricular radiotherapy (WVRT).

Methods and materials

Dosimetric data for patients with NGGCT prospectively enrolled in stratum 1 of the Children's Oncology Group study ACNS1123 who received 30.6 Gy WVRT were compared. Target segmentation was standardized using a contouring atlas. Doses to cranial OARs were compared between proton and photon treatments. Clinically relevant dose-volume parameters that were analyzed included mean dose and dose to 40% of the OAR volume (D40).

Results

Mean and D40 doses to the supratentorial brain, cerebellum, and bilateral temporal, parietal, and f

SUBMITTER: Mak DY 

PROVIDER: S-EPMC9329212 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature