Metastatic Death Based on Presenting Features and Treatment for Advanced Intraocular Retinoblastoma: A Multicenter Registry-Based Study.

ABSTRACT:

Purpose

To evaluate presenting features, tumor size, and treatment methods for risk of metastatic death due to advanced intraocular retinoblastoma (RB).

Design

International, multicenter, registry-based retrospective case series.

Participants

A total of 1841 patients with advanced RB.

Methods

Advanced RB was defined by 8th edition American Joint Committee on Cancer (AJCC) categories cT2 and cT3 and new AJCC-Ophthalmic Oncology Task Force (OOTF) Size Groups (1: < 50% of globe volume, 2: > 50% but < 2/3, 3: > 2/3, and 4: diffuse infiltrating RB). Treatments were primary enucleation, systemic chemotherapy with secondary enucleation, and systemic chemotherapy with eye salvage.

Main outcome measures

Metastatic death.

Results

The 5-year Kaplan-Meier cum

SUBMITTER: Tomar AS 

PROVIDER: S-EPMC9329221 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature