Isoniazid preventive therapy and tuberculosis transcriptional signatures in people with HIV.

ABSTRACT:

Objectives

To examine the association between isoniazid preventive therapy (IPT) or nontuberculous mycobacteria (NTM) sputum culture positivity and tuberculosis (TB) transcriptional signatures in people with HIV.

Design

Cross-sectional study.

Methods

We enrolled adults living with HIV who were IPT-naive or had completed IPT more than 6 months prior at HIV care clinics in western Kenya. We calculated TB signatures using gene expression data from qRT-PCR. We used multivariable linear regression to analyze the association between prior receipt of IPT or NTM sputum culture positivity with a transcriptional TB risk score, RISK6 (range 0-1). In secondary analyses, we explored the association between IPT or NTM positivity and four other TB transcriptional signatures.

Resu

SUBMITTER: Valinetz ED 

PROVIDER: S-EPMC9329226 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature