Early EEG hyperexcitability is associated with decreased survival in newly diagnosed IDH-wildtype glioma.

ABSTRACT:

Purpose

The relationship between peritumoral neuronal activity, early onset clinical seizures, and glioma survival outcomes remains poorly understood. Hyperexcitability on continuous EEG in the peri-operative period was studied as a prognostic biomarker in patients with newly diagnosed IDH-wildtype diffuse glioma.

Methods

A retrospective observational cohort study was performed including adults with newly diagnosed diffuse glioma, absence of IDH1/2 mutations, and continuous EEG monitoring prior to chemoradiation and within 1 month of initial resection. EEG hyperexcitability was defined by the presence of lateralized periodic discharges and/or electrographic seizures. The primary outcome of overall survival was estimated using the Kaplan-Meier method and compared between grou

SUBMITTER: Tobochnik S 

PROVIDER: S-EPMC9329255 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature