Polygenic Resilience Modulates the Penetrance of Parkinson Disease Genetic Risk Factors.

ABSTRACT:

Objective

The aim of the current study is to understand why some individuals avoid developing Parkinson disease (PD) despite being at relatively high genetic risk, using the largest datasets of individual-level genetic data available.

Methods

We calculated polygenic risk score to identify controls and matched PD cases with the highest burden of genetic risk for PD in the discovery cohort (International Parkinson's Disease Genomics Consortium, 7,204 PD cases and 9,412 controls) and validation cohorts (Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease, 8,968 cases and 7,598 controls; UK Biobank, 2,639 PD cases and 14,301 controls; Accelerating Medicines Partnership-Parkinson's Disease Initiative, 2,248 cases and 2,817 controls).

SUBMITTER: Liu H 

PROVIDER: S-EPMC9329258 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature