Elevated CD4 + T-cell glucose metabolism in HIV+ women with diabetes mellitus.

ABSTRACT:

Objective

Immune dysfunction and chronic inflammation are characteristic of HIV infection and diabetes mellitus, with CD4 + T-cell metabolism implicated in the pathogenesis of each disease. However, there is limited information on CD4 + T-cell metabolism in HIV+ persons with diabetes mellitus. We examined CD4 + T-cell glucose metabolism in HIV+ women with and without diabetes mellitus.

Design

A case-control study was used to compare CD4 + T-cell glucose metabolism in women with HIV with or without diabetes mellitus.

Methods

Nondiabetic (HIV+DM-, N = 20) or type 2 diabetic HIV+ women with (HIV+DM+, N  = 16) or without (HIV+DMTx+, N  = 18) antidiabetic treatment were identified from the WIHS and matched for age, race/ethnicity, smoking status and CD4 + cell count. CD4 +

SUBMITTER: Butterfield TR 

PROVIDER: S-EPMC9329261 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature