Mitochondrial function and Aβ in Alzheimer's disease postmortem brain.

ABSTRACT:

Introduction

Mitochondrial dysfunction is observed in Alzheimer's disease (AD). However, the relationship between functional mitochondrial deficits and AD pathologies is not well established in human subjects.

Methods

Post-mortem human brain tissue from 11 non-demented (ND) and 12 AD subjects was used to examine mitochondrial electron transport chain (ETC) function. Data were analyzed by neuropathology diagnosis and Apolipoprotein E (APOE) genotype. Relationships between AD pathology and mitochondrial function were determined.

Results

AD subjects had reductions in brain cytochrome oxidase (COX) function and complex II Vmax. APOE ε4 carriers had COX, complex II and III deficits. AD subjects had reduced expression of Complex I-III ETC proteins, no changes were observed

SUBMITTER: Troutwine BR 

PROVIDER: S-EPMC9329272 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature