Maternal obesity, gestational weight gain, and offspring asthma and atopy.

ABSTRACT:

Background

Maternal obesity may affect offspring asthma and atopic disease risk by altering fetal immune system development. However, few studies evaluate gestational weight gain (GWG).

Objective

To evaluate relationships between maternal body mass index (BMI), GWG, and persistent wheeze, eczema, allergy, and asthma risk in offspring through middle childhood.

Methods

A total of 5939 children from Upstate KIDS, a population-based longitudinal cohort of children born in upstate New York (2008-2019) were included in the analysis. Persistent wheeze or asthma, eczema, and allergy were maternally reported at multiple study time points throughout early and middle childhood. Poisson regression models with robust SEs were used to estimate adjusted risk ratios (aRRs) and 95% co

SUBMITTER: Polinski KJ 

PROVIDER: S-EPMC9329274 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature