Identification of candidate enhancers controlling the transcriptome during the formation of interphalangeal joints.

ABSTRACT: The formation of the synovial joint begins with the visible emergence of a stripe of densely packed mesenchymal cells located between distal ends of the developing skeletal anlagen called the interzone. Recently the transcriptome of the early synovial joint was reported. Knowledge about enhancers would complement these data and lead to a better understanding of the control of gene transcription at the onset of joint development. Using ChIP-sequencing we have mapped the H3-signatures H3K27ac and H3K4me1 to locate regulatory elements specific for the interzone and adjacent phalange, respectively. This one-stage atlas of candidate enhancers (CEs) was used to map the association between these respective joint tissue specific CEs and biological processes. Subsequently, integrative analysis of t

SUBMITTER: Nowosad K 

PROVIDER: S-EPMC9329285 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature