Label-free, real-time detection of perineural invasion and cancer margins in a murine model of head and neck cancer surgery.

ABSTRACT: Surgical management of head and neck cancer requires a careful balance between complete resection of malignancy and preservation of function. Surgeons must also determine whether to resect important cranial nerves that harbor perineural invasion (PNI), as sacrificing nerves can result in significant morbidity including facial paralysis. Our group has previously reported that Dynamic Optical Contrast Imaging (DOCI), a novel non-invasive imaging system, can determine margins between malignant and healthy tissues. Herein, we use an in vivo murine model to demonstrate that DOCI can accurately identify cancer margins and perineural invasion, concordant with companion histology. Eight C3H/HeJ male mice were injected subcutaneously into the bilateral flanks with SCCVIISF, a murine head and neck c

SUBMITTER: Tam K 

PROVIDER: S-EPMC9329308 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature