Hepatokine Fetuin B expression is regulated by leptin-STAT3 signalling and associated with leptin in obesity.

ABSTRACT: Obesity is an expanding global public health problem and a leading cause of metabolic disorders. The hepatokine Fetuin B participates in regulating insulin resistance, glucose metabolism and liver steatosis. However, the mechanism underlying Fetuin B activation remains unclear. Our previous population-based study demonstrated a significant association between serum Fetuin B and body fat mass in an obese population, which indicates its potential in mediating obesity-related metabolic disorders. In the present study, we further revealed a significant correlation between Fetuin B and leptin, the classic adipokine released by expanding adipose tissue, in this obese population. Consistently, elevated Fetuin B and leptin levels were confirmed in diet-induced obese mice. Furthermore, an in vitro

SUBMITTER: Wang D 

PROVIDER: S-EPMC9329397 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature