Alcohol consumption in relation to cardiovascular diseases and mortality: a systematic review of Mendelian randomization studies.

ABSTRACT: The causal effects of alcohol-in-moderation on cardiometabolic health are continuously debated. Mendelian randomization (MR) is an established method to address causal questions in observational studies. We performed a systematic review of the current evidence from MR studies on the association between alcohol consumption and cardiometabolic diseases, all-cause mortality and cardiovascular risk factors. We performed a systematic search of the literature, including search terms on type of design and exposure. We assessed methodological quality based on key elements of the MR design: use of a full instrumental variable analysis and validation of the three key MR assumptions. We additionally looked at exploration of non-linearity. We reported the direction of the studied associations. Our sea

SUBMITTER: van de Luitgaarden IAT 

PROVIDER: S-EPMC9329419 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature