Assessing agreement between different polygenic risk scores in the UK Biobank.

ABSTRACT: Polygenic risk scores (PRS) are proposed for use in clinical and research settings for risk stratification. However, there are limited investigations on how different PRS diverge from each other in risk prediction of individuals. We compared two recently published PRS for each of three conditions, breast cancer, hypertension and dementia, to assess the stability of using these algorithms for risk prediction in a single large population. We used imputed genotyping data from the UK Biobank prospective cohort, limited to the White British subset. We found that: (1) 20% or more of SNPs in the first PRS were not represented in the more recent PRS for all three diseases, by the same SNP or a surrogate with R² > 0.8 by linkage disequilibrium (LD). (2) Although the difference in the are

SUBMITTER: Clifton L 

PROVIDER: S-EPMC9329440 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature