A new approach to broaden the range of eye colour identifiable by IrisPlex in DNA phenotyping.

ABSTRACT: IrisPlex system represents the most popular model for eye colour prediction. Based on six polymorphisms this model provides very accurate predictions that strongly depend on the definition of eye colour phenotypes. The aim of the present study was to introduce a new approach to improve eye colour prediction using the well-validated IrisPlex system. A sample of 238 individuals from a Southern Italian population was collected and for each of them a high-resolution image of eye was obtained. By quantifying eye colour variation into CIELAB space several clustering algorithms were applied for eye colour classification. Predictions with the IrisPlex model were obtained using eye colour categories defined by both visual inspection and clustering algorithms. IrisPlex system predicted blue and brow

SUBMITTER: Paparazzo E 

PROVIDER: S-EPMC9329466 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature