MicroRNA miR-7 Is Essential for Post-stroke Functional Recovery.

ABSTRACT: Transient focal ischemia induces a sustained downregulation of miR-7 leading to derepression of its target α-synuclein (α-Syn), which promotes neuronal death. We previously showed that treatment with miR-7 mimic prevents α-Syn induction and protects brain after stroke in rodents irrespective of age and sex. To further decipher the role of miR-7, we currently studied infarction and motor function in miR-7 double knockout mice (lack both miR-7a and miR-7b) subjected to focal ischemia. Adult miR-7^-/- mice showed similar motor and cognitive functions to miR-7^+/+ mice. However, when subjected to even a mild focal ischemia, the miR-7^-/- mice showed exacerbated brain damage and worsened motor function compared with the miR-7^+/+ mice. Replenishing miR-7

SUBMITTER: Mehta SL 

PROVIDER: S-EPMC9329483 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature