Identification of Sex-Specific Plasma Biomarkers Using Metabolomics for Major Depressive Disorder in Children and Adolescents.

ABSTRACT:

Background

Children and adolescents are at a high risk of major depressive disorder (MDD) with known sex differences in epidemiology. However, there are currently no objective laboratory-based sex-specific biomarkers available to support the diagnoses of male and female patients with MDD.

Methods

Here, a male set of 42 cases and 27 healthy controls (HCs) and a female set of 42 cases and 22 HCs were recruited. This study investigated the sex differences of plasma metabolite biomarkers in young patients with MDD by the application of ultra-high-performance liquid chromatography equipped with quadrupole time-of-flight mass spectrometry.

Results

The metabolic profiles showed clear separations in both male and female sets. In total, this study identified 57 male-related an

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC9329558 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature