Long-Term Treatment With Letrozole in a Boy With Familial Male-Limited Precocious Puberty.

ABSTRACT:

Background

The long-term follow-up in children with familial male-limited precocious puberty (FMPP) who were treated with letrozole, triptorelin, and spironolactone is limited, especially considering the efficiency and safety.

Objective

We describe the clinical characteristics and long-term treatment with letrozole on adult height of a boy diagnosed with FMPP, confirmed by analysis of the LHCGR gene.

Methods

Physical examinations, bone age (BA), testosterone, and gonadotropin levels were measured as well as gene sequencing of the proband and parents.

Results

The boy was referred to the hospital at 3.1 years of age due to peripheral precocious puberty. His height was 116.8cm (+5.1SD) and BA was 9 years. Genetic analysis revealed a patrilineal c.1703C>T.(p.Ala568

SUBMITTER: Yuan X 

PROVIDER: S-EPMC9329579 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature