Altered Glucose Metabolism and Glucose Transporters in Systemic Organs After Bariatric Surgery.

ABSTRACT: The Roux-en-Y gastric bypass (RYGB) is highly effective in the remission of obesity and associated diabetes. The mechanisms underlying obesity and type 2 diabetes mellitus remission after RYGB remain unclear. This study aimed to evaluate the changes in continuous dynamic FDG uptake patterns after RYGB and examine the correlation between glucose metabolism and its transporters in variable endocrine organs using ¹⁸F-fluoro-2-deoxyglucose positron emission tomography images. Increased glucose metabolism in specific organs, such as the small intestine and various fat tissues, is closely associated with improved glycemic control after RYGB. In Otsuka Long-Evans Tokushima Fatty rats fed with high-fat diets, RYGB operation increases intestine glucose transporter expression and various

SUBMITTER: Oh JH 

PROVIDER: S-EPMC9329688 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature